Endocrine Abstracts

Background: Many chemicals present within the environment, as well as natural and artificial components of our diet, have the potential to interfere with the physiological role of hormones, interfering with hormone biosynthesis, signalling or metabolism. In the last years AMH, a protein secreted by granulosa cells, has emerged as a reliable marker of ovarian reserve. It is largely accepted the influence of age and smoking on AMH serum levels, although a clear effect of environ...

Anti-Mullerian hormone (AMH), a member of transforming growth factor β (TGF-β), shows different sex-related functions. In male, from the fetal development till the puberty, the expression of AMH by Sertoli cells causes regression of Mullerian ducts with subsequent testicular differentiation. Mainly studied in female, AMH produced by ovarian granulosa cells inhibits both initiation of primordial follicle growth and the FSH-stimulated follicle growth. Moreover, recent ...

Introduction: FSH acts on its receptor (FSHR) resulting in signal transduction activation, gene expression and steroidogenesis. The FSHR common SNP p.N680S is a marker of gonadal response in vivo. However, in vitro dose–response experiments failed to demonstrate the molecular basis thereof so far. In this study, we systematically investigated whether p.N680S mediates different kinetics of FSH response in vitro.Des...